Status:
COMPLETED
Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Hoffmann-La Roche
Conditions:
Febrile Neutropenia
Endocarditis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The primary purpose is to improve and quicken the microbial diagnosis in severe infections, since only one third of the cases are documented by blood cultures and adequate anti-infective therapy in th...
Detailed Description
We will evaluate the advantage of adding the molecular test to the microbial investigations usually done (blood cultures and others) in cases of febrile neutropenia, suspicion of infective endocarditi...
Eligibility Criteria
Inclusion
- Age≥ 18 years
- Written signed and dated inform consent
- First time with fever observed in a neutropenic patient
- Severe sepsis in a patient hospitalized in ICU
- Suspicion of infective endocarditis
- Microbial investigation from Monday to Friday
Exclusion
- Not affiliated to Health Insurance (social security)
- Included in another interventional trial testing microbial DNA detection during the time "without Septifast®"
- Included in another clinical trial for which the clinician assumes that it will not be possible to prescribe an anti-infectious therapy adequately to microbial detection in the blood
- Patient previously included in the protocol
- Sepsis with a microbial diagnosis
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT00709358
Start Date
May 1 2008
End Date
September 1 2010
Last Update
December 29 2011
Active Locations (1)
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1
CHU Henri Mondor
Créteil, France