Status:
COMPLETED
An Open Study Comparing the Effects of Moxaverine on Ocular Blood Flow in Patients With Age- Related Macular Degeneration, Primary Open Angle Glaucoma and Healthy Control Subjects
Lead Sponsor:
Medical University of Vienna
Conditions:
Macular Degeneration
Glaucoma
Eligibility:
All Genders
50+ years
Phase:
PHASE2
PHASE3
Brief Summary
A number of common eye diseases such as age-related macular degeneration and glaucoma are associated with ocular perfusion abnormalities. Although this is well recognized there is not much possibility...
Eligibility Criteria
Inclusion
- Men and women aged over 50 years
- Ametropia of less than 6 diopters and anisometropia of less than 2 diopters
- Clear non-lenticular ocular media
- AMD patients:
- Patients with nonexudative AMD
- Visual acuity in the study eye \> 20/60
- Glaucoma patients:
- Unilateral or bilateral primary open angle glaucoma
- At least 3 reliable visual field testings
- Treated intraocular pressure \< 21 mmHg,
- Visual field mean deviation MD \<10 (Humphrey 30-2)
- Healthy control subjects:
- Age- , gender- and sex- matched to the two patient groups,
- Matched with regard to smoking habits of the two patient group
- No observable eye diseases
Exclusion
- History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of the study drug
- Blood donation during the previous 3 weeks
- Abuse of alcoholic beverages or drugs, participation in a clinical trial in the 3 weeks preceding the study
- Known diabetes mellitus
- Presence of any ocular pathology that interferes with the aims of the present study
- Intraocular surgery within the last 3 weeks
- Hypersensitivity to moxaverine
- Acute gastric bleeding, massive cerebral hemorrhage related to stroke
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2009
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00709449
Start Date
May 1 2008
End Date
March 1 2009
Last Update
December 1 2009
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090