Status:
COMPLETED
Evaluation of the Role of Nocturnal Non-Invasive Ventilation in Pulmonary Rehabilitation
Lead Sponsor:
Deutsche Lungenstiftung e.V.
Collaborating Sponsors:
Hannover Medical School
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
18+ years
Brief Summary
Hypothesis: Hospital based, comprehensive pulmonary rehabilitation of patients with COPD in GOLD stage IV can be optimized by application of nocturnal non invasive ventilation. This hypotheses shall ...
Detailed Description
Non invasive ventilation is known to allow improvements if applied during endurance training, but this is technically difficult. Nocturnal application of non invasive ventilation is known to unload th...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of COPD in stages GOLD IV
- Receiving optimized medical treatment and long term oxygen treatment, if indicated
- Patient's consent to participate in this trial
Exclusion
- Previous treatment with NIPPV
- Unwillingness or intolerance to perform NIPPV
- Acute exacerbation of COPD at baseline or during pulmonary rehabilitation,
- Significant orthopaedic or neurologic problems that reduce mobility or cooperation with physical training
- Poor controlled coexisting psychiatric or unstable cardiac disease,
- Inability to perform a six minute walk test
- Extreme hypercapnia (pCO2 \> 74 mmHg)
Key Trial Info
Start Date :
May 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00710463
Start Date
May 1 2003
End Date
November 1 2007
Last Update
July 4 2008
Active Locations (1)
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1
Klinikum Berchtesgadener Land
Berchtesgaden, Germany, D-83471