Status:
COMPLETED
Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With Chordomas
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Chordoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Before radiation treatment is given to treat chordomas, CT and MRI scans are used to create a three dimensional picture of the tumor using x-rays. The CT and MRI scans are used to determine the size a...
Detailed Description
* In this research study we are determining whether the positron emission tomography (PET) investigation performed with the investigational radioactive substance FMISO can show areas of tumor with low...
Eligibility Criteria
Inclusion
- Skull base and spinal chordomas diagnosis based on pathology review by Department of Pathology at Massachusetts General Hospital
- Patient to be treated with proton or combined photon RT for primary CD or recurrent CD after surgery
- 18 years of age or older
- Karnofsky Score of 60% or greater
- Gross tumor mass larger than 1cm (maximal diameter on MRI)
Exclusion
- Recurrences after RT
- Pregnancy
- Allergic reaction to FMISO injection
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00713037
Start Date
June 1 2008
End Date
June 1 2016
Last Update
February 3 2017
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02214