Status:
COMPLETED
Incretin Physiology Associated With Steroid Hormone Treatment
Lead Sponsor:
Glostrup University Hospital, Copenhagen
Conditions:
Type 2 Diabetes Mellitus
Steroids
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate whether the reduced incretin effect and the paradoxical glucagon responses during oral glucose ingestion and isoglycaemic iv glucose infusion observed in patie...
Detailed Description
The incretin effect is severely reduced in patients with type 2 diabetes. This pathophysiological trait is accompanied by an almost abolished insulinotropic effect of the incretin hormone glucose-depe...
Eligibility Criteria
Inclusion
- Caucasians without Type 2 or Type 1 Diabetes
- Normal OGTT (75 g of glucose) according to WHO criteria
- Normal hemoglobin
- Normal blood pressure
Exclusion
- Liver disease
- Kidney disease
- Relatives (parents/siblings) with type 2 diabetes
- Pregnancy
- Contra-indications to treatment with adrenocortical steroids
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00713440
Start Date
July 1 2008
End Date
January 1 2009
Last Update
August 6 2009
Active Locations (1)
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1
Clinical Physiology Department; Glostrup Univesity Hospital
Glostrup Municipality, Capital Region, Denmark, 2600