Status:
COMPLETED
Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
Emory University
Conditions:
Mild Cognitive Impairment
Alzheimer's Disease
Eligibility:
All Genders
18-88 years
Phase:
PHASE1
Brief Summary
Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI...
Eligibility Criteria
Inclusion
- General inclusion criteria (all patients):
- A minimum of 12 years of education or attainment of a Graduation Equivalency Diploma;
- All medications stable for approximately 3 months;
- No history of severe mental illness;
- No current untreated alcohol or substance abuse/dependence;
- English as native and preferred language;
- MRI-compatible if taking part in fMRI studies 7) Able to give informed consent.
- MCI
- Diagnosis of amnestic MCI based on criteria set forth by Petersen (2004). Additionally, other potential causes of cognitive deficit ruled out by the referring physician;
- 55 years of age or older.
- TBI Inclusion criteria:
- History of a mild to moderate TBI;
- No history of other neurological disease or injury;
- A minimum of 6 months and maximum of 5 years post-onset of TBI;
- 18 - 45 years old.
Exclusion
- History of neurological disease or injury (other than TBI)
- History of severe mental illness
- Current untreated alcohol or substance abuse
- Other conditions may exclude; please discuss with contact
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT00714571
Start Date
July 1 2008
End Date
September 1 2014
Last Update
January 4 2017
Active Locations (1)
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1
Atlanta VA Medical and Rehab Center, Decatur
Decatur, Georgia, United States, 30033