Status:
COMPLETED
Combined Therapy With L-Thyroxine and L-Triiodothyronine Compared to L-Thyroxine Alone
Lead Sponsor:
I.M. Sechenov First Moscow State Medical University
Conditions:
Hypothyroidism
Eligibility:
FEMALE
18-48 years
Phase:
NA
Brief Summary
The objective of this study was to analyze the features of monotherapy with L-T4 in comparison with combined therapy with L-T4 and L-T3 in patients with primary hypothyroidism.
Detailed Description
We conducted a randomized controlled study with a crossover design in 36 premenopausal women with overt primary hypothyroidism (reduced T4 concentration accompanied by increased TSH concentration at t...
Eligibility Criteria
Inclusion
- Premenopausal women with overt primary hypothyroidism (reduced T4 concentration accompanied by increased TSH concentration at the time of initial diagnosis) who did not receive thyroid hormones
Exclusion
- Peri- and postmenopause
- Pregnancy
- Major comorbidity
- Use of drugs that affect metabolism or bioavailability of thyroid hormones preparations.
Key Trial Info
Start Date :
March 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2004
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00715572
Start Date
March 1 2002
End Date
May 1 2004
Last Update
July 15 2008
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