Status:
COMPLETED
Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Lead Sponsor:
University of Utah
Conditions:
Atelectasis
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to determine whether breathing high levels of oxygen during surgery affects oxygen levels after surgery. The second purpose of this study is to determine whether giving po...
Detailed Description
This is a randomized, controlled, blinded trial in patients undergoing non-abdominal surgery of the effect of intraoperative increased inspired oxygen used (FiO2\>0.9 vs. FiO2 = 0.3) on non-invasive o...
Eligibility Criteria
Inclusion
- Patients aged 18-70 years undergoing surgery under general endotracheal anesthesia at the University of Utah Hospital Operating Room and the Huntsman Cancer Hospital Operating room who will be admitted to the hospital for at least 24 hours after surgery
Exclusion
- Major (open) abdominal surgery
- Major spine surgery
- Craniotomy surgery
- Surgeries where electrocautery or laser devices may be used near the airway (eg tracheostomy, oral surgery) because of the risk of fire with high inspired oxygen in these cases
- Procedures planned for monitored anesthesia care (MAC) or regional without general anesthesia
- Planned airway management with a laryngeal mask airway rather than an endotracheal tube
- Procedures planned in the prone position because this increases atelectasis
- Planned postoperative intubation
- Planned postoperative care in the intensive care unit
- Recent (within 3 weeks) chemotherapy because of the increased risk of pulmonary oxygen toxicity
- History of bleomycin administration because of the increased risk of pulmonary oxygen toxicity
- Diagnosed Obstructive Sleep Apnea with home continuous pulmonary airway pressure (CPAP) use
- Home oxygen use
- Preoperative room air (RA) SpO2 \<90%
- History of spontaneous pneumothorax
- Emergency surgery
- Pregnancy. Women of child-bearing age are routinely screened for pregnancy urine human chorionic gonadotropin, (HCG) on the morning of surgery. Patients with a positive result will be excluded from the study (and most likely will have their elective surgery cancelled).
- Patient refusal
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00715741
Start Date
June 1 2008
End Date
July 1 2009
Last Update
February 18 2010
Active Locations (1)
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1
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84132