Status:
UNKNOWN
A Pilot Study of Inflammatory Markers in Alzheimer's Disease
Lead Sponsor:
McMaster University
Collaborating Sponsors:
The Physicians' Services Incorporated Foundation
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
50+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to examine the cerebrospinal fluid (CSF) of patients with Alzheimer's disease for biomarkers of inflammation and their response to the antibiotics doxycycline and rifampin...
Detailed Description
Doxycycline and rifampicin are two antibiotics which may be useful in the treatment of Alzheimer's disease (AD). Besides their antimicrobial effects they may also decrease specific contributors to AD ...
Eligibility Criteria
Inclusion
- Giving informed consent to lumbar puncture
- Participation in the DARAD clinical trial which requires the following:
- diagnosis of probable Alzheimer's disease
- SMMSE 14-26 inclusive
- community-dwelling
- age 50 or greater
- caregiver to monitor study medication and report on ADLs, behaviour, etc.
- adequate English literacy to complete neuropsychological testing
- generally stable level of health
Exclusion
- Contraindication to lumbar puncture
- DARAD exclusion criteria as follows:
- dementia due to other neurodegenerative diseases
- cognitive impairment due to head trauma, etc.
- stroke or significant cerebrovascular disease
- clinically significant cardiac disease such as recent MI, uncontrolled hypertension
- taking other anti-dementia treatments or investigational drugs
- allergy to doxycycline or rifampin
- significant psychiatric conditions like depression
- cancer
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00715858
Start Date
May 1 2008
End Date
October 1 2009
Last Update
February 4 2009
Active Locations (1)
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1
St.Peter's Hospital
Hamilton, Ontario, Canada, L8M1W9