Status:
UNKNOWN
The Effect of Left Ventricular Filling Pressure on Pulmonary Clearance of Free Radical Loaded White Blood Cells and Platelets in Congestive Heart Failure Patients Before and After Biventricular Pacing
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
Brief Summary
1. To assess whether a correlation exist between the degree of pulmonary clearance of free radical positive white bloodcells and platelets and the degree of pulmonary congestion in congestive heart fa...
Detailed Description
Evidence exists that oxidative stress is enhanced in congestive heart failure patients resulting in damage to cellular lipids, proteins and DNA. Because of free radical-induced apoptosis of skeletal m...
Eligibility Criteria
Inclusion
- Patient selection
- Informed consented participants are recruited among all patients admitted to the OLVG hospital.
- Inclusion criteria:
- Chronic congestive heart failure patients of all ages selected for biventricular pacemaker implantation for resynchronization therapy
- Dyspnoe NYHA class III and IV
- Optimal and constant heart failure treatment according to the ESC guidelines
- Exclusion criteria:
- Renal failure (creatinine \> 1.70 mg/dl)
- Signs of infection or inflammation
Exclusion
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00716885
Start Date
September 1 2008
End Date
September 1 2009
Last Update
July 16 2008
Active Locations (1)
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1
OLVG Hospital
Amsterdam, North Holland, Netherlands, 1090hm