Status:
COMPLETED
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
Lead Sponsor:
City of Hope Medical Center
Collaborating Sponsors:
National Cancer Institute (NCI)
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Chronic Myeloproliferative Disorders
Leukemia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cel...
Detailed Description
OBJECTIVES: * To document the quantitative characteristics of a cytomegalovirus (CMV)-specific HLA-peptide tetramer-binding assay (TBA) for cytotoxic T lymphocytes (CTLs) in patients who have undergo...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria at the City of Hope National Medical Center:
- Patient who has undergone a matched-related or matched-unrelated allogeneic bone marrow or peripheral blood stem cell transplantation (SCT) for a hematological malignancy (e.g., aplastic anemia or myelodysplastic syndromes)
- At risk for cytomegalovirus (CMV) infection and disease due to 1 of the following risk factors:
- CMV-seropositive prior to transplantation
- Received SCT from a CMV-seropositive donor
- Donor for matched-related SCT
- Healthy volunteer evaluated concurrently with SCT recipients to establish normal values for both CMV-seronegative and CMV-seropositive persons
- Any HLA serotypes allowed
- PATIENT CHARACTERISTICS:
- See Disease Characteristics
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
January 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2007
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00716911
Start Date
January 1 2000
End Date
July 1 2007
Last Update
June 8 2015
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