Status:
UNKNOWN
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype
Lead Sponsor:
National University Hospital, Singapore
Conditions:
Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Primary 1. To determine the presence and frequency of novel and known UGT1A6 and UGT2B7 polymorphisms in healthy Chinese, Malay and Indian subjects. 2. To determine the presence and frequency of nove...
Detailed Description
Germline polymorphisms are inherited genetic variation present in all cells of the body. At molecular level, such variations may affect gene transcription, translation, mRNA stability, protein activit...
Eligibility Criteria
Inclusion
- Inclusion criteria for stage I study
- Subjects \>= 18 years old
- Hemoglobin \>= 8g/dL, Total white cell counts \>3.0 x 103/μl
- ECOG =0
- Inclusion criteria for stage II study
- Chinese ethnicity
- Patients \>18 years old
- Hemoglobin =\> 8g/dL, Total white cell counts \>3.0 x 103/μl
- Histologically or cytologically confirmed lung cancer for stage II study
- Uncontrolled medical conditions such as diabetes, hypertension and coronary artery disease.
- Exclusion criteria
- Histology of small cell lung cancer
- Medical or psychiatric conditions which may impair the patient's ability to provide informed consent.
Exclusion
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00717353
Start Date
October 1 2005
Last Update
January 14 2014
Active Locations (1)
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1
National University Hospital
Singapore, Singapore