Status:
TERMINATED
The Effects of Glucose/Ischemic Preconditioning on Reperfusion Injury in Deceased-Donor Liver Transplantation
Lead Sponsor:
University Health Network, Toronto
Conditions:
Liver Transplantation
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
Standard liver retrieval procedures for transplantation from a deceased donor inevitably result in a "reperfusion injury" to the liver tissue. The purpose of this research study is to find out whether...
Detailed Description
Liver transplantation is the only chance of cure for patients with end-stage liver disease. Unfortunately, standard organ preservation results in an ischemic-reperfusion injury (IRI) at the time of gr...
Eligibility Criteria
Inclusion
- Recipient 18 years of age or older
- Recipient with chronic end-stage liver disease
- Deceased donor liver transplant
- Recipient capable of providing written informed consent
- Whole organ graft from donors aged 60 years or older
Exclusion
- Fulminant liver failure
- Objection by any other member of the retrieval team
- Split-liver grafts
- Donor that has received total parenteral nutrition within 24hr of organ retrieval Donors from whom the pancreas and/or small bowel are also being retrieved
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00718575
Start Date
August 1 2008
End Date
March 1 2012
Last Update
July 25 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Health Network (Toronto General Hospital)
Toronto, Ontario, Canada, M5G 2N2