Status:
TERMINATED
Lidocaine and Ketamine in Abdominal Surgery
Lead Sponsor:
The Cleveland Clinic
Conditions:
Abdominal Hysterectomy (& Wertheim)
Eligibility:
FEMALE
18-75 years
Phase:
NA
Brief Summary
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hystere...
Detailed Description
Subjects undergoing abdominal hysterectomy surgery are randomized into one of four groups: Intravenous Lidocaine, Intravenous Ketamine, Intravenous Lidocaine and Ketamine or Placebo. Subjects will per...
Eligibility Criteria
Inclusion
- Age greater than 18 years old and less than 75 years years old
- Horizontal abdominal incision
Exclusion
- Emergency or urgent procedure
- Preexisting chronic pain (at any site) requiring treatment
- Contraindication to any study medication (ketamine or lidocaine)
- History of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.)
- Significant hepatic (ALT or AST \> 2 times normal) or renal (serum creatinine \> 2 mg/dl) impairment
- Seizure disorder requiring medication within past 2 years
- Planned spinal or epidural anesthesia or analgesia
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00721110
Start Date
July 1 2008
End Date
July 1 2012
Last Update
July 26 2017
Active Locations (1)
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1
Cleveland Clinic/Hillcrest Hospital
Mayfield Heights, Ohio, United States, 44124