Status:
COMPLETED
Skeletal Muscle Properties and the Metabolic Cost of Walking Post-stroke
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
Medical University of South Carolina
Conditions:
Stroke
Eligibility:
All Genders
18-80 years
Brief Summary
Of the \~700,000 persons who suffer a stroke each year, only 50% recover the ability to perform unlimited community walking. One mechanism contributing to locomotor dysfunction post-stroke is an incre...
Detailed Description
A guiding principle of the proposed research is that skeletal muscle is the building block of all movement and, as such, muscle dysfunction can ultimately limit the gains possible from rehabilitation ...
Eligibility Criteria
Inclusion
- age 18-80;
- stroke within past 6 months - 5 years;
- residual paresis in the lower extremity (LE) (Fugl-Meyer motor score \<34);
- ability to sit unsupported for 30 sec;
- ability to walk at least 10 ft with maximum 1 person assist;
- self selected 10 meter gait speed \< 0.8 m/s; and
- provision of informed consent.
Exclusion
- Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking \< 200 meters;
- history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living;
- History of chronic obstructive pulmonary disease or oxygen dependence;
- Preexisting neurological disorders, dementia or previous stroke;
- History of major head trauma;
- Legal blindness or severe visual impairment;
- history of significant psychiatric illness;
- Life expectancy \<1 yr;
- Severe arthritis or orthopedic problems that limit passive range of motion (ROM);
- post-stroke depression (PHQ-9 10);
- History of deep vein thrombosis (DVT) or pulmonary embolism within 6 months;
- Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions;
- Severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest;
- Previous or current enrollment in a clinical trial to enhance motor recovery;
- Presence of non-magnetic resonance (MR) compatible implants or devices, pregnancy or severe claustrophobia.
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00721357
Start Date
August 1 2008
End Date
September 1 2013
Last Update
March 18 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, United States, 29401-5799