Status:
COMPLETED
Effect of IV Lidocaine Infusions on Pain
Lead Sponsor:
Stanford University
Conditions:
Pain
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Our goals for this study involve using intravenous lidocaine as it is normally used in the Stanford Pain Management Center to assess the effect of intravenous lidocaine on chronic pain. Studies have b...
Detailed Description
Each patient will receive an intravenous infusion of lidocaine. Drug will be infused using a computer-controlled paradigm. This paradigm allows increasing plasma concentrations in a step-wise manner, ...
Eligibility Criteria
Inclusion
- subjects between the ages of 18 and 100 years for clinical component; subjects between the ages of 18 and 70 for the MRI component
- meets the study criteria of chronic pain of either peripheral or central origin
- male or a non-pregnant, non-lactating female. If females are of reproductive potential (i.e., not surgically sterilized and/or not post menopausal), they must be practicing an accepted method of birth control, agree to a urine pregnancy test at the start of each study session (for patient scheduled through the clinic, this has already been addressed by the recommending physician)
- is not currently on a sodium channel blocking agent, anticonvulsant, or tricyclic antidepressant,
- must be able to comply with any other study requirements and complete experimental tasks
- have no reported substance abuse within the past six months;
Exclusion
- subject is lactating or pregnant;
- subject suffers from clinically significant cardiac, pulmonary, renal or liver disease;
- subject allergic to lidocaine.
- MRI Component: any metal objects (especially surgical clips), devices, or implants or any other MRI contraindication
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT00725504
Start Date
September 1 2008
End Date
February 1 2011
Last Update
February 15 2019
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305