Status:
COMPLETED
Assessment of Thrombogenicity in Acute Coronary Syndrome
Lead Sponsor:
Newcastle-upon-Tyne Hospitals NHS Trust
Collaborating Sponsors:
British Heart Foundation
University of Newcastle Upon-Tyne
Conditions:
Type 2 Diabetes Mellitus
Acute Coronary Syndrome
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to assess platelet dependent thrombogenicity in patients after acute coronary syndrome using an ex vivo arterial injury model.
Detailed Description
Abnormal platelet activity seen in patients with Type2 Diabetes Mellitus (T2DM) may be an important contributor to their enhanced cardiovascular risk and higher rates of cardiovascular events followin...
Eligibility Criteria
Inclusion
- Acute coronary syndrome (WHO criteria) with raised cardiac troponin T
- Aged 18-80 years
- Stable Acute coronary syndrome
- On aspirin and clopidogrel
- Willing to participate in the study
Exclusion
- Smoking (current smokers or smokers who quit in the last 6 months preceding recruitment)
- Malignancy (any suspected or proven)
- Haematological disorders (bleeding disorders)
- Pre-menopausal women
- Use of corticosteroids/other antithrombotic agents (warfarin)
- Chronic liver disease
- Unable to consent
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00728286
Start Date
October 1 2008
End Date
May 1 2011
Last Update
October 12 2015
Active Locations (1)
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1
Royal Victoria Hospital, Newcastle upon Tyne Hospitals NHS Trust
Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP