Status:
COMPLETED
Functional Implications of TNF
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Bronchitis
Eligibility:
All Genders
18-35 years
Brief Summary
The research plan proposes to develop translational studies in humans that will identify host susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone. Ozone is a ubiqui...
Detailed Description
Exposure of the airways to air toxins initiates transient and reversible airway injury to both adults and young children. Repetitive exposures of children residing within high oxidant communities lead...
Eligibility Criteria
Inclusion
- \-
Exclusion
- subjects with current or past smoking history, acute respiratory illness within six weeks of the study, and significant non-pulmonary disease as determined by the investigator, pregnancy, age \<18 or \>35 yr, or inability to understand the protocol. Subjects will be requested to refrain from anti-histamines, nonsteroidal anti-inflammatory agents, and supplemental vitamins, e.g. C and E, for 1 week prior to, and during lab visits for exposures and follow-up measures.
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00729131
Start Date
August 1 2008
End Date
February 1 2012
Last Update
September 29 2014
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710