Status:
COMPLETED
Vasopressin, Epinephrine, and Steroids for Cardiac Arrest
Lead Sponsor:
University of Athens
Collaborating Sponsors:
University of Thessaly
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The simultaneous activation of adrenergic and vasopressin receptors, in conjunction with a potential steroid-mediated enhancement of the vascular reactivity to epinephrine may have beneficial effects ...
Detailed Description
Background and Rationale Inhospital cardiac arrest still constitutes an important clinical problem with survival to discharge ranging within 0-42% (most common range = 15-20%) (1). Survival after witn...
Eligibility Criteria
Inclusion
- Adult patients with refractory inhospital cardiac arrest, defined as epinephrine requirement for ventricular fibrillation/tachycardia or asystole/pulseless electrical activity according to guidelines for resuscitation 2005 (5).
Exclusion
- Age \< 18 years
- Terminal illness or do-not resuscitate status
- Cardiac arrest due to exsanguination
- Cardiac arrest before hospital admission
- Pre-arrest treatment with intravenous corticosteroids
- Previous enrollment in or exclusion from the current study
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00729794
Start Date
September 1 2008
End Date
November 1 2010
Last Update
November 21 2016
Active Locations (3)
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1
Evaggelismos General Hospital
Athens, Attica, Greece, GR-10675
2
401 General Military Hospital of Athens
Athens, Attica, Greece, GR-11526
3
University General Hospital of Larissa
Larissa, Thessaly, Greece, GR-41110