Status:
COMPLETED
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia
Lead Sponsor:
Samsung Medical Center
Conditions:
Benign Prostatic Hyperplasia
Eligibility:
MALE
50+ years
Phase:
NA
Brief Summary
In this study, we investigate the changes of the expression of alpha adrenergic receptor in the prostate tissue during 2-yr medication period in the man with benign prostatic hyperplasia. And we also ...
Detailed Description
To compare the expression of alpha-1 adrenergic receptors, we will use various methodologies such as * Real-time RT-PCR * Radioligand receptor binding * Western blot * Immunohistochemistry
Eligibility Criteria
Inclusion
- 50 yrs or greater
- International prostatic symptom score \>= 8
- Maximal flow rate \< 15mL/sec
- baseline PSA 2.5-10 ng/mL
- Pathologically proven BPH
- No medication history for BPH
- Able to give fully informed consent
Exclusion
- Previous use of alpha-blocker, 5-alpha reductase inhibitor
- Previous surgery for BPH
- Urologic cancer history
- Urethral stricture
- baseline PSA \> 10ng/mL
- BP \< 90/70 mmHg
- Orthotopic hypotension with syncope
- Serum Cr \> 2.0 mg/dl, alanine aminotransferase \> 1.5 times of normal limit
- Bacterial prostatitis within 1 year
- Urinary tract infection(UTI) more than 2 times within 1 year
- Active UTI or prostate biopsy within 1 month
- Unable to void
- Ped use because of incontinence
- Hypersensitivity to alpha-blocker that include quinazoline
- Unstable angina, Myocardial infarction, or cerebrovascular accident within 6 months
- Neurogenic bladder dysfunction (ex. multiple sclerosis, Parkinson's disease, Spinal injury etc.)
- Psychiatric problem
- Alcohol abuse or other drug abuse history
- Severe comorbidities unable to perform long-term trial
- seems not to be appropriate to this study because of any other reasons
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00730418
Start Date
January 1 2007
End Date
March 1 2010
Last Update
August 26 2010
Active Locations (1)
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1
Samsung Medical Center
Seoul, South Korea, 135-710