Status:
UNKNOWN
Association Study of Gene Polymorphisms With Cardiac Performance
Lead Sponsor:
University Hospital, Essen
Conditions:
Genetic Polymorphism
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.
Detailed Description
G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the ...
Eligibility Criteria
Inclusion
- clinical diagnosis of coronary artery disease
- patients scheduled for coronary artery bypass grafting
Exclusion
- emergency operation
- combined vitium
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2011
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT00730899
Start Date
May 1 2008
End Date
June 1 2011
Last Update
August 8 2008
Active Locations (1)
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1
University Hospital
Essen, North Rhine-Westphalia, Germany, 45147