Status:
WITHDRAWN
In-Vitro Studies in Depletion of Haplotype Mismatched Alloreactive T Cells
Lead Sponsor:
Indiana University School of Medicine
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Hematologic Malignancies
Hematopoietic Stem Cell Transplantation
Eligibility:
All Genders
18+ years
Brief Summary
The doctors in the Bone Marrow Transplant Service at the Indiana University Cancer Center are working to better understand how the immune cells that cause graft-versus-host disease (a major complicati...
Detailed Description
The purpose of this research is to study how immune cells (called T cells) that cause graft-versus-host disease (GVHD) can best be selectively separated from other T cells and removed from the cells t...
Eligibility Criteria
Inclusion
- Patients with hematological malignancies who are undergoing evaluation for autologous or allogeneic stem cell transplants will be eligible, if: (1)They have no circulating neoplastic cells in the peripheral blood as assessed by routine morphology or flow cytometry. (2)Patients with acute myeloid or lymphocytic leukemia are in complete remission
- First-degree relatives of patients evaluated for stem cell transplantation will be eligible if: (1) Willing to undergo testing for HIV and hepatitis B and C (free of charge) (2) Not pregnant at time of collection of blood (3)In good general health (4) No prior history of malignancy. (5) Age 18 years or older if donating apheresis product. (Because of the relatively invasive nature of the leukopheresis procedure and difficulties in obtaining consent, children \<18 who are first degree relatives of the patient will not undergo apheresis for studies on this protocol)
- Written informed consent
Exclusion
- \-
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00731705
Start Date
January 1 2007
End Date
January 1 2010
Last Update
September 19 2014
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