Status:
COMPLETED
Minocycline for the Treatment of Early-Phase Schizophrenia
Lead Sponsor:
Shalvata Mental Health Center
Collaborating Sponsors:
Abarbanel Mental Health Center
Conditions:
Negative and Cognitive Symptoms in Schizophrenia
Eligibility:
All Genders
18-35 years
Phase:
PHASE3
Brief Summary
Current antipsychotics have only a limited effect on two core symptoms of schizophrenia, negative symptoms and cognitive deficits. Minocycline is a second-generation tetracycline which has a beneficia...
Detailed Description
Schizophrenia is a disorder characterized by disturbances in perception, thought, volition, socialization, psychomotor behavior and the sense of self. Although patients suffer from schizophrenia start...
Eligibility Criteria
Inclusion
- age between 18-35 years;
- current DSM-IV diagnosis of schizophrenia confirmed by the Structured Clinical Interview for DSM-IV (SCID) conducted by a trained psychiatrist.
- being at an early phase of the disorder (i.e., within five years of their first exposure to neuroleptic treatment;18)
- did not receive antipsychotic treatment for six months preceding current symptom exacerbation;
- baseline total score of more than 60 on the Positive and Negative Syndrome Scale (PANSS).
- Initiation of treatment with atypical antipsychotic medication equal or less than 14 days prior to study entry (risperidone, olanzapine, quetiapine, or clozapine; 200-600 mg/day chlorpromazine equivalent doses);
- able to comprehend the procedure and aims of the study.
Exclusion
- acute, unstable, significant or untreated medical illness beside schizophrenia;
- pregnant or breast-feeding females;
- A DSM-IV diagnosis of substance abuse or dependency;
- Known contraindication to minocycline treatment.
- Treatment with minocycline or Beta-lactam antibiotics in the preceding half year before study entry.
- Under compulsory hospitalization.
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2007
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT00733057
Start Date
August 1 2003
End Date
March 1 2007
Last Update
August 12 2008
Active Locations (1)
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1
The Emotion-Cognition Research Center, The Shalvata Mental Health Care Center, P.O.B. 94.
Hod HaSharon, Israel, 70300