Status:
COMPLETED
Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Lung Dysfunction
Inflammatory Response During Cardiac Surgery
Eligibility:
All Genders
18+ years
Brief Summary
The hypotheses of this study are that: * Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans; * The inc...
Detailed Description
In this project, we will test the hypothesis that cys-leukotrienes are released and correlated with the impairment of the lung function after cardiac surgery in patients with COPD. If such hypothesis ...
Eligibility Criteria
Inclusion
- Adult patients schedules to undergo cardiac surgery with use of CPB.
Exclusion
- inability to provide consent;
- previous diagnosis of asthma;
- acute pre-operative respiratory failure;
- emergency surgery.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00734266
Start Date
April 1 2007
End Date
December 1 2010
Last Update
March 6 2013
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