Status:
COMPLETED
Facilitation of Fear Extinction With Yohimbine Hydrochloride in Phobic Participants
Lead Sponsor:
VU University of Amsterdam
Conditions:
Phobic Disorders
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
Procedurally Virtual reality exposure therapy (VRET) is quite similar to models of extinction of conditioned fears. Recent advances in animal research have identified pharmacological agents that appea...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of specific phobia (fear of flying).
- Between the ages of 18-65
- Sufficient fluency in Dutch to complete treatment and research protocol
Exclusion
- Presence of medical condition, assessed by self-report questionnaires at the intake (i.e., pregnancy, seizure disorder, respiratory disorder, cardiovascular disease, pacemaker, hypertension).
- Resting blood pressure higher than 140 (systolic) or 105 (diastolic)
- Unstable psychotropic medication.
- Current use of tranquilizers (Benzodiazepines)
- Psychosis
- Depression with suicidal ideation
- Dementia or other severe cognitive impairment
- Substance dependence
- Bipolar disorder
- Borderline personality disorder
- Anti-social personality disorder
- Current use of beta-blockers
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT00734422
Start Date
July 1 2008
End Date
July 1 2010
Last Update
September 13 2018
Active Locations (1)
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1
University of Amsterdam
Amsterdam, Netherlands