Status:
COMPLETED
Study to Evaluate the Protective Effect of α-Keto Acid With Low-protein Diet on Renal Function in PD Patients
Lead Sponsor:
Sun Yat-sen University
Conditions:
Peritoneal Dialysis
Eligibility:
All Genders
20-75 years
Phase:
NA
Brief Summary
This randomized, open-label, prospective study will evaluate the renal effective effect of compound α-Keto Acid plus low protein diet in PD Patients.
Detailed Description
Residual renal function (RRF) is associated with cardiovascular complication, nutritional status, incidence of peritonitis, and quality of life in peritoneal dialysis (PD) patients. Therefore, RRF is ...
Eligibility Criteria
Inclusion
- Patients on PD at least one month prior to study entry.
- Subjects of either sex, more than 20 years old, the range of age is 20 to 75 year old.
- Residual GFR ≥3 ml/min/1.73m2.
- Residual urine volume ≥ 500 ml/24h.
- No history of taking α-Keto Acid within 2 weeks.
- Subjects who agree to participate in the study and sign the informed consent.
Exclusion
- History of peritonitis or other infection within one month.
- History of taking drug which may affect amino acid metabolism within one month.
- Incapable of following study requirements to control diet.
- With severe cardiovascular disease, chronic liver disease, dyscrasia, psychiatric disorder, alcohol or drug abuse.
- Participation in another clinic trial within one month prior to screening.
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00734552
Start Date
October 1 2007
End Date
May 1 2010
Last Update
May 22 2015
Active Locations (1)
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1
The 1st Affiliated Hospital, Sun Yet-sen University
Guangzhou, Guangdong, China, 510080