Status:
COMPLETED
Striatal and Extra-striatal Mechanisms of Falling in Parkinson's Disease
Lead Sponsor:
University of Michigan
Conditions:
Parkinson's Disease
Eligibility:
All Genders
50-85 years
Brief Summary
This research study will evaluate functions of memory, thinking, eye movements and walking and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using ...
Detailed Description
Although most research in PD has a focus on presynaptic dopaminergic denervation, new lessons may be learned by exploring to what extent alterations in non-motor and non-dopaminergic systems may play ...
Eligibility Criteria
Inclusion
- Subjects considered for inclusion will be female or male subjects either currently enrolled or eligible for care at the VA aged 50-85 years, or community volunteers.
- The racial, gender and ethnic characteristics of the proposed subjects population reflect the demographics of the patient population of the VA. However, extra efforts will be made to recruit women and minorities (see table 5).
- Children will be excluded from the study.
- No exclusion criteria shall be based on race, ethnicity, gender, or asymptomatic HIV status.
Exclusion
- Inability to stand or walk independently (i.e., patients in Hoehn and Yahr stage IV and V).
- Vertiginous disorder.
- Orthostatic hypotension or unstable cardiovascular disease at risk of syncope (drop in systolic blood pressure of \> 20 mm Hg upon standing).
- History of stroke with focal cortical lesions.
- Cerebellar, myelopathic or significant radiculopathy syndrome.
- Diminished light perception in both eyes (\< 20/40 corrected OU).
- Intracranial surgery.
- Subjects who have participated in other research protocols such that their cumulative radiation absorbed dose to whole body, gonads, bone marrow or lens of the eye would exceed 5 Rem, or dose to other body organs is more than 15 Rem in preceding 12 months.
- Pregnancy (beta-HCG test within 48 hours of PET study) or breastfeeding.
- Contra-indications to MRI.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00736671
Start Date
July 1 2006
End Date
August 1 2010
Last Update
March 4 2016
Active Locations (1)
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1
University of Michigan Functional Neuroimaging, Cognnitive and Mobility Laboratory
Ann Arbor, Michigan, United States, 48106