Status:
TERMINATED
Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Lead Sponsor:
Rush University Medical Center
Conditions:
Osteoarthritis
Eligibility:
All Genders
19-80 years
Phase:
NA
Brief Summary
This study involves research. The purpose of this research is to formally investigate the hemostatic efficacy of epinephrine to minimize blood loss after total joint arthroplasty. It is unclear if usi...
Detailed Description
Total hip and knee arthroplasties are associated with considerable blood loss, and can conservatively range from 480 ml to 1.39 liters. Current research has focused on the prevention of allogeneic blo...
Eligibility Criteria
Inclusion
- Patients must be male or female of any race
- Ages 18-80yr
- Patients must be undergoing hip or knee arthroplasty
- Patients must be able to understand and be willing to cooperate with study procedures
- Patient must not take platelet inhibiting drugs for 10 days before surgery
- Able to provide written and verbal informed consent
- Preoperative hemoglobin above 12g/dl
- Osteoarthritis as the primary indication for knee arthroplasty, and either osteoarthritis or avascular necrosis as the indication for total hip arthroplasty
Exclusion
- Allergy or intolerance to the study materials or medications
- Surgical intervention during the past month for the treatment of the painful joint or its underlying etiology
- History of any substance abuse or dependence within the last 6 months
- Patients who have received an investigational drug or device in the past 30 days
- Affected joint has undergone prior open surgery
- Patient received epoetin alfa 30 days before surgery
- Pre-operative autologous blood donation
- Use of platelet inhibiting drugs 10 days prior to surgery
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00737139
Start Date
September 1 2008
End Date
April 1 2012
Last Update
August 31 2012
Active Locations (1)
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1
Rush University Medical Center
Chicago, Illinois, United States, 60612