Status:
TERMINATED
In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter
Lead Sponsor:
Northwell Health
Conditions:
GERD
Barretts Esophagus
Eligibility:
All Genders
18-75 years
Brief Summary
The purpose of this study is: * To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure ...
Detailed Description
The purpose of this research study is to examine and evaluate a part of the digestive system (gastrointestinal tract). The specific part the study team will look at is called the "lower esophageal sph...
Eligibility Criteria
Inclusion
- Inclusion criteria for GERD patients are:
- Symptomatic heartburn
- Regurgitation
- Chest pain or water brash
Exclusion
- Exclusion criteria for normal volunteers include:
- Medications-Subjects on any medication which could effect the gastroesophageal junction high-pressure zone will be excluded, this includes use of antacids, H2 blockers, proton pump inhibitors, prokinetic agents, erythromycin type antibiotics and anticholinergics.
- GI symptoms, conditions and disorders
- In addition exclusion criteria will include a history of:
- Esophagitis
- Gastrointestinal symptoms such as abdominal pain
- Heartburn
- Reflux
- Regurgitation
- Chest pain
- Difficulty swallowing
- Pain on swallowing
- Dysphagia
- Abdominal surgery involving the stomach or esophagus
- Nausea or vomiting
- Diabetes
- Scleroderma
- Esophageal motility disorders
- Non cardiac chest pain
- Achalasia and current pregnancy.
Key Trial Info
Start Date :
April 12 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 3 2017
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00737802
Start Date
April 12 2013
End Date
February 3 2017
Last Update
February 22 2019
Active Locations (1)
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1
LIJ Medical Center- NSLIJ Health System
New Hyde Park, New York, United States, 11040