Status:
UNKNOWN
Free Soft Tissue Graft in Treatment of Oral Lichen Planus
Lead Sponsor:
Qazvin University Of Medical Sciences
Conditions:
Oral Lichen Planus
Eligibility:
All Genders
40-70 years
Phase:
PHASE1
Brief Summary
Oral lichen planus is a common chronic mucocutaneous disease with various clinical forms. Erosive-ulcerative forms usually cause symptoms of pain and discomfort. The most important complication of OLP...
Detailed Description
Oral lesions in OLP are chronic ,rarely undergo spontaneous remission, are potentially premalignant and are often a source of morbidity. recent study does not support that non reticular OLP are more p...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Biopsy confirmed symptomatic oral lichen planus: WHO histological criteria in combination with clinical appearance will be used for diagnosis
- Previous routine treatment modalities has been attempted including steroids and immunomodulatory or antioxidant agents. i.e patients who had resistant lesions to routine treatment .removal of possible triggering drugs was also considered.
- Patients of both sexes between 40 to 70 year's old
- Patients who have symptoms such as burning sensation, pain
- Patients who have localized precancerous lesions such as atrophic-erosive/plaque like lichen planus with diameter lesser than 2 cm
- Patients who agree to this treatment
- Patients who are willing for evaluation in first week after surgery and every two month for 1 years
- Patients who agree to final punch biopsy for histopathologic evaluation
- Exclusion criteria:
- Patients who unable to undergo oral surgery
- Patients suffering from any localized or systemic disease
- Pregnant patients
- Smokers
- Patients who can not continue the study for private or social reasons
- Patients with generalized oral lichen planus
Exclusion
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00737854
Start Date
May 1 2008
End Date
December 1 2010
Last Update
December 11 2008
Active Locations (1)
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1
Qazvin University of Medical Sciences
Qazvin, Qazvin State, Iran, 3415759811