Status:
COMPLETED
Bioavailability of Flavonoids and Phenolic Acids From Cranberry Juice Cocktail in Healthy Older Adults
Lead Sponsor:
Tufts University
Collaborating Sponsors:
Ocean Spray, Inc.
Conditions:
Healthy
Eligibility:
All Genders
50-70 years
Phase:
NA
Brief Summary
This is a single-dose, pharmacokinetic study investigating the bioavailability of flavonoids and phenolic acids from cranberry juice cocktail and their breakdown products (in vivo metabolites) in heal...
Detailed Description
Cranberries are a particularly rich source of phenolic acids and polyphenols, particularly flavonoids. Among the 20 most commonly consumed fruits in the American diet, cranberries have the highest tot...
Eligibility Criteria
Inclusion
- Men and postmenopausal women
- BMI 18.5-29.9 kg/m2
Exclusion
- Cigarette smoking and/or nicotine replacement use
- Use of cholesterol-lowering medications
- Use of blood pressure-lowering medications
- Use of any stomach acid-lowering medications
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure \> 150 mm Hg and/or diastolic blood pressure \> 95 mm Hg
- Regular use of oral steroids
- Regular daily intake of 2 or more alcoholic drinks
- Illicit drug use
- No fish oil supplements (including cod liver oil) for one month prior to study admission
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00740077
Start Date
August 1 2008
End Date
January 1 2009
Last Update
February 9 2009
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111