Status:
UNKNOWN
The Effects of a Positive Expiratory Pressure (PEP) on Dyspnea and Dynamic Hyperinflation During Exercise in Chronic Obstructive Pulmonary Disease (COPD) Patients
Lead Sponsor:
Khon Kaen University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
Up to 70 years
Phase:
NA
Brief Summary
From the relationship between pathophysiology of chronic obstructive pulmonary disease (COPD), dyspnea, and dynamic hyperinflation during ventilatory increasing, the investigators hypothesize that 1....
Detailed Description
Expiratory airflow limitation is the pathophysiological hallmark of chronic obstructive pulmonary disease (COPD) that leads to air trapping and increases in dynamic hyperinflation (DH) and consequentl...
Eligibility Criteria
Inclusion
- Patients with stable mild-to-moderate COPD (Both stages: FEV1/FVC \< 70%. Mild stage: FEV1 ≥ 80% predicted; Moderate stage: 50% ≤ FEV1 \< 80% predicted according to Global Initiative Obstructive Lung Disease (GOLD) guideline).
- Free of exacerbations for more than 4 weeks (as defined by a change to pharmacological therapy, admission to hospital or ER or unscheduled clinic visit).
- Good communication
Exclusion
- Older than 70 years old
- Musculoskeletal problems that limit mobility
- Cardiovascular disease
- Neurological or psychiatric illness
- Patient on long term oxygen or domiciliary noninvasive positive pressure ventilation
- Any other comorbidities which would affect ability to undertake exercise test
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2009
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00741832
Start Date
March 1 2008
End Date
February 1 2009
Last Update
November 14 2008
Active Locations (1)
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1
Pulmonary research room of physical therapy department, Faculty of associated medical sciences, Khon Kaen university
Khon Kaen, Changwat Khon Kaen, Thailand, 40002