Status:
UNKNOWN
Rapid Versus Prolonged Inpatient Up-Titration of Captopril
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Heart Disease
Eligibility:
All Genders
Up to 18 years
Phase:
PHASE2
Brief Summary
The primary objective of this study is to establish a safe and effective method of up-titration of captopril for hospital inpatients.
Detailed Description
Angiotensin converting enzyme inhibitors (ACEi) are one of the most frequently prescribed pediatric cardiac medication and overall their safety in children is widely accepted. Pediatric formulary reco...
Eligibility Criteria
Inclusion
- Pediatric cardiology in-patients at The Hospital for Sick Children
- Primary physician has decided to commence ACEi (the division has agreed that our institutional choice will be to start patients on captopril and up-titrate to optimal dose before converting to other ACEi)
- Patients who have been initiated on captopril within the prior 24 hours, but have not yet started up-titration, will be eligible to be randomized
Exclusion
- Known sensitivity to ACEi
- Infants on the neonatal intensive care unit
- Treatment with any ACEi for more than 24 hours within the preceding 6 months
- Age \> 18 years
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00742040
Start Date
August 1 2008
End Date
December 1 2009
Last Update
August 27 2008
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada