Status:
COMPLETED
Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study will examine whether pretreatment with D-cycloserine before cognitive behavioral therapy can reduce impairments still present in people with stable cases of schizophrenia as well as determi...
Detailed Description
Schizophrenia is a debilitating chronic condition that affects approximately 1 % of Americans, who experience symptoms such as hallucinations, delusions, and disorders of thought and movement. These s...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for schizophrenia, schizoaffective disorder, or schizophrenia, paranoid subtype, based on chart review, Structured Clinical Interview for DSM-IV, and consultation with the patient's clinicians
- Medicated with an antipsychotic agent other than clozapine at a stable dose for at least 6 weeks
- Scores at least 3, or "moderate," on the Scale for the Assessment of Positive Symptoms global delusion rating
- Paranoid or referential delusional content
- Never engaged in formal CBT psychotherapy in the past
Exclusion
- Diagnosis of a comorbid Axis I disorder other than schizophrenia
- Active substance abuse or dependence within 6 months
- Significant suicidal ideation within 6 weeks
- Pregnant or nursing
- Unstable medical disorder
- impaired renal clearance (creatinine \<60mg/dL/min)
- Suffering from dementia
- Suffering from seizure disorder
Key Trial Info
Start Date :
September 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00742079
Start Date
September 1 2006
End Date
December 1 2010
Last Update
December 19 2017
Active Locations (1)
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1
MGH Schizophrenia Program - Freedom Trail Clinic
Boston, Massachusetts, United States, 02114