Status:
TERMINATED
Women With Chest Pain and Normal Coronary Arteries Study
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
Astellas Pharma US, Inc.
Conditions:
Chest Pain
Eligibility:
FEMALE
30-90 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the effectiveness of standard medical therapy versus usual care in women with chest pain, coronary endothelial dysfunction and unblocked coronary arteries. Cor...
Detailed Description
Endothelial function testing will be performed on women without significant coronary disease in order to help identify women who may be likely to develop coronary artery disease (CAD) and who would be...
Eligibility Criteria
Inclusion
- Female gender
- Age 30 or greater
- Present with symptoms suggestive of Angina (Typical or "Atypical")
- Abnormal myocardial perfusion scan
- Referred for angiography
- Normal (0% stenosis) versus Nonobstructive coronary artery disease (CAD) (\<50% stenosis)
- Evidence of endothelial dysfunction.
Exclusion
- Coronary vasospasm known or documented in cardiac catheterization
- Obstructive CAD (greater than 50% stenosis) known or documented in cardiac catheterization
- Pregnancy
- Established CAD, history of revascularization with percutaneous transluminal coronary angioplasty (PTCA)/stent or coronary artery bypass graft (CABG)
- Contraindications to magnetic resonance imaging (MRI)
- Cardiac catheterization for valvular disease
- Cardiac catheterization for heart failure assessment/biopsy
- Known congestive heart failure (CHF)/hypertrophic obstructive cardiomyopathy (HOCM)/dilated cardiomyopathy (DCM)
- Acute Renal Failure
- Chronic renal failure (estimated glomerular filtration rare (eGFR) \<30 ml/min/1.73m\^2) or on hemodialysis
- Known single kidney
- History of peptic ulcer disease, known gastrointestinal bleed, known contraindication to aspirin
- Known contraindication to statin
- Known contraindication to adenosine (asthma, high degree atrial ventricular (AV) block)
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT00743197
Start Date
May 1 2008
End Date
May 1 2010
Last Update
December 12 2023
Active Locations (1)
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1
Northwestern University
Chicago, Illinois, United States, 60611