Status:
COMPLETED
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Umeå University
Conditions:
Coronary Disease
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
Detailed Description
Air pollution is a major problem, and can be linked to around 5% of all deaths worldwide each year. There are strong associations between air pollution exposure and heart disease but we do not yet und...
Eligibility Criteria
Inclusion
- Healthy male volunteers
Exclusion
- Use of regular medication
- Cigarette smoking
- Significant occupational exposure to air pollution
- Intercurrent illness
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00745693
Start Date
March 1 2008
End Date
May 1 2008
Last Update
May 17 2024
Active Locations (1)
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1
Umeå University
Umeå, Västerbottens, Sweden, SE-901 87