Status:
COMPLETED
Efficacy of Fish Oil Supplementation on Cognition in MCI Patients and the Influence of the APOE4 Allele
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
Radboud University Medical Center
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
Phase:
NA
Brief Summary
To study the short term effects of a pharmacological dose of fish oil on cognitive performance and on cerebral blood flow. Furthermore, we want to investigate whether carriers of the APOEε4 allele res...
Eligibility Criteria
Inclusion
- Men and women
- Diagnosed as having amnestic MCI: based on specific memory disturbances (cut-off of 1 sd, single or multiple domain amnestic MCI, according to Busse A et al37)
- Presence of a principal caregiver willing to assist for a successful participation
- Informed consent signed
Exclusion
- Current or recent (\<4 weeks) use of fish oil supplements
- Consumption of fish more than 2 times/week
- Current use of dementia (Alzheimer) medication
- Current use of acenocoumarol or other anti-thrombotic drugs (because of the high dose of fish oil)
- Serious liver disease
- Use of more than 4 glasses of alcohol per day
- Unable to participate as judged by the responsible medical physician
- Allergy to fish(oil)
- Swallowing problems
- Participation in another clinical trial less than 2 months before the start of the trial or at the same time
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00746005
Start Date
October 1 2008
End Date
January 1 2011
Last Update
January 12 2011
Active Locations (2)
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1
Ziekenhuis Gelderse Vallei
Ede, Gelderland, Netherlands, 6710 HN
2
Radboud University Medical Center
Nijmegen, Gelderland, Netherlands, 6525 GC