Status:
COMPLETED
Study of the Relationships Between Refractory Hypertension, Overweight/Obesity and Sleep Apnea Syndrome
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
Fondation de Recherche sur l'Hypertension Artérielle
Conditions:
Refractory Hypertension
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
The purpose of the study is to investigate the links between blood pressure (BP), overweight or obesity, and sleep apnea syndrome (SAS), by studying a large cohort of subjects suffering from refractor...
Detailed Description
A number of factors predispose subjects to both hypertension and SAS, including overweight/obesity and hyperinsulinism. The pathogenesis of concomitant overweight/obesity and hypertension is multifact...
Eligibility Criteria
Inclusion
- Patients of either gender, of between 18 and 70
- Suffering from refractory hypertension as defined by persistent clinical hypertension (\> 140/90 mm Hg according to two different readings 24 hours apart) despite at least three classes of antihypertensive drugs (including a thiazide diuretic) at appropriate doses.
- Recruited in the Cardiology Departments of the University Hospitals in Grenoble, Toulouse, Marseille and Poitiers, and in the Mozart Clinic in Paris.
- Outpatients
- Patients who have signed the consent form
- Patients affiliated to or beneficiary of the social security system
Exclusion
- Failure to fulfil the inclusion criteria
- Treated SAS, whatever the form of the treatment
- Disease which might affect BP regulation, including Parkinson's disease, kidney or heart transplantation, dysautonomia, severe heart failure
- Atrial fibrillation or regular extrasystole (\> 10/minute)
- Night- or shift-work
- Pregnant and breast-feeding women
- Patients under legal guardianship
- Incarcerated patients or adults protected by the law
- Hospitalised patients
- Ongoing participation in another clinical research study
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT00746902
Start Date
June 1 2008
End Date
September 1 2014
Last Update
November 7 2014
Active Locations (1)
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1
University Hospital
Grenoble, France