Status:
TERMINATED
Dopamine in Orthostatic Tolerance
Lead Sponsor:
Vanderbilt University
Conditions:
Postural Tachycardia Syndrome
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will al...
Eligibility Criteria
Inclusion
- Upright plasma norepinephrine \> 600 pg/ml, or
- An increase in heart rate of \> 30 beats per minute upon standing, and
- Withdrawal of all medications for at least 3 days, and
- No associated medical illness, and
- Age 18 - 60 years old.
Exclusion
- Older than 60 years of age
- Routinely taking medications affecting the autonomic nervous system
- Any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic) other than POTS
- Anemia (Hct \< 30)
- Women of childbearing age who are pregnant or nursing
- Unable to give informed consent
Key Trial Info
Start Date :
November 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00748228
Start Date
November 1 2004
End Date
July 1 2012
Last Update
June 15 2015
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37232