Status:
TERMINATED
Colonography Versus Colonoscopy in High Risk Patient
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
to evaluate the acceptability of CT-colonography compared to colonoscopy for the detection of advanced adenomas in subpopulations at high risk of colorectal.
Detailed Description
Secondary objective: to evaluate the medical and economic impact of the implementation of CT- colonography in this setting.Methodology: prospective multicenter randomized controlled trial with direct ...
Eligibility Criteria
Inclusion
- Surveillance of patients with a personal history of advanced adenoma or CRC:
- Informed consent obtained
- Age ≥ 18 and ≤ 80 years old
- History of advanced adenomatous polyps
- Or history of non metastatic CRC with curative surgery and without other treatment more than 2 years before enrollment.
- Previous medical examination
- Screening of patients with a Family history of CRC at high risk:
- Informed consent obtained
- Age ≥ 18 and ≤ 80 years old
- First degree family history of colorectal cancer diagnosed \<60yrs during the five previous years-Previous medical examination
Exclusion
- Personal histories
- Age \< 18 or \>80 years old
- history of non adenomatous polyps
- history of Metastatic CRC
- familial adenomatous polyposis, Peutz-Jeghers syndrome, hereditary non polyposis colorectal cancer (HNPCC), juvenile polyposis syndrome
- Familial history of familial adenomatous polyposis
- Personal history of subtotal colectomy (but not of hemicolectomy, to confer to inclusion criteria)
- Colonoscopy with a polyps resection dated more than 5 years and less than 2 years prior to enrollment.
- Enrollment in another protocol
- no health insurance affiliation Family histories
- Age \< 18 or \>80 years old
- Patients with one or several family histories of first degree colorectal cancer occured to unknown age or diagnosed after 60 years old.
- Eligible patients having already undergone colonoscopy screening
- no health insurance affiliation
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT00748449
Start Date
June 1 2008
End Date
December 1 2010
Last Update
September 12 2011
Active Locations (1)
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1
Cochin
Paris, France, 75014