Status:
TERMINATED
Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency
Lead Sponsor:
Cytokinetics
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose for this study (CY 1124) is to evaluate the effects of CK-1827452, a cardiac myosin activator, on myocardial systolic performance, myocardial oxygen consumption, and myocardial efficiency ...
Eligibility Criteria
Inclusion
- Clinical indication for left and right heart catheterization
- Willing and able to provide informed consent
- Male or female 18 years of age or greater
- Symptomatic heart failure (≥ NYHA Class II)
- Ejection fraction ≤ 35%
- Patient is in sinus rhythm
- Patient is considered to be in suitable health in the opinion of the investigator, as determined by:
- o A pre-study physical examination with no clinical abnormalities which in the opinion of the investigator would preclude participation in the study other than physical symptoms or signs consistent with stable heart failure
- For female patients only: Post-menopausal or sterilized, or if she is of childbearing potential, she is not breastfeeding, her pregnancy test is negative, she has no intention to become pregnant for up to 90 days following the study, and she is using contraceptive drugs or devices
Exclusion
- Acute myocarditis
- Hypertrophic, restrictive, or constrictive cardiomyopathy
- Congenital heart disease
- Known left ventricular thrombus
- Significant stenotic valvular disease (severe aortic stenosis, mitral stenosis)
- Poorly controlled hypertension (SBP \> 180 mmHg)
- Pacemaker dependent ventricular rhythm
- Detectable troponin or CK-MB \> ULN at any timepoint within 14 days of enrollment
- Acute coronary syndrome or revascularization procedure within 30 days of enrollment
- ≥ 50% stenosis of the left main coronary artery
- Plan for immediate revascularization procedure (PCI or CABG)
- GFR ≤ 35 ml/min/1.73 m2 by Modification of Diet in Renal Disease (MDRD) Equation or need for renal replacement therapy
- Known hepatic impairment (total bilirubin \> 3 mg/dL, or ALT and AST \> 2 times the upper limit of normal)
- Has received an investigational drug or device within 30 days before enrollment
- Has had any prior treatment with CK-1827452
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00748579
Start Date
September 1 2008
End Date
July 1 2009
Last Update
January 21 2020
Active Locations (3)
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1
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21205
2
UUHSC / Division of Cardiology
Salt Lake City, Utah, United States, 84132
3
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5