Status:
COMPLETED
Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
6-18 years
Phase:
NA
Brief Summary
This study will examine the way cognitive behavioral therapy changes the structure of the brain in patients with obsessive-compulsive disorder and will thereby determine what makes cognitive behaviora...
Detailed Description
Obsessive-compulsive disorder (OCD) afflicts 2% to 4% of children and adolescents, who suffer from persistent, unwanted thoughts and repetitive behaviors. One of the most effective treatments of OCD i...
Eligibility Criteria
Inclusion
- Meets DSM-IV diagnostic criteria for OCD as primary diagnosis, based on the Anxiety Disorders Interview Schedule (ADIS) Clinical Severity Rating
- Clinical Global Impressions severity score of at least 4, reflecting moderately ill or worse status
- Children's Yale-Brown Obsessive Compulsive Scale total score of greater than or equal to 16
- No medication for OCD or other psychiatric condition in the past 4 weeks and no use of fluoxetine for the past 6 weeks
- Child is fluent in English
- Parental informed consent and child or adolescent informed assent forms are signed
- For females of childbearing potential a negative pregnancy test will be required for study entry
Exclusion
- IQ of less than 80 on the Wechsler Abbreviated Scales of Intelligence
- A lifetime DSM-IV diagnosis of pervasive developmental disorder, mania, psychosis, conduct disorder, or substance dependence assessed through ADIS
- Current DSM-IV diagnosis of major depressive disorder or attention deficit hyperactivity disorder any subtype, assessed through an ADIS rating of 4 or higher
- Any serious psychiatric, psychosocial, or neurological condition, such as a tic disorder, non-OCD anxiety, aggression, or family discord, that requires immediate treatment other than that provided in the current study
- One or more failed adequate trials of exposure-based CBT, defined as at least 10 sessions of therapist-assisted, exposure-based CBT with which the patient voluntarily complied
- More than one failed selective serotonin reuptake inhibitor trial adequate in dose and duration, defined as at least 8 weeks of treatment with at least 20 mg of fluoxetine, 20 mg of paroxetine, 75 mg of sertraline or fluvoxamine, or 75mg of clomipramine
- Any body metal (other than dental fillings), pregnancy, or other contraindications to MRSI scan
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2016
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT00748761
Start Date
June 1 2008
End Date
December 31 2016
Last Update
March 25 2020
Active Locations (1)
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1
UCLA Child Psychiatry
Los Angeles, California, United States, 90024