Renoprotective Effects of Fluid Prophylaxis Strategies for Contrast Induced Nephropathy (CIN)

Status:

WITHDRAWN

Renoprotective Effects of Fluid Prophylaxis Strategies for Contrast Induced Nephropathy (CIN)

Lead Sponsor:

Memorial University of Newfoundland

Collaborating Sponsors:

University of Alberta

Conditions:

Contrast Induced Nephropathy

Eligibility:

All Genders

20+ years

Phase:

PHASE4

Brief Summary

Contrast induced nephropathy (CIN) is a term applied to acute renal failure associated with intravascular injection of iodinated contrast agents typically used for cardiac angiography. CIN occurs in a...

Detailed Description

Study Design We propose a pilot randomized trial evaluating the type of fluid chosen for CIN prophylaxis. This study will be conducted at the Health Sciences Centre, St. John's, and the University of ...

Eligibility Criteria

Inclusion

Booked for cardiac angiography and/or percutaneous coronary intervention
Pre-existing reduced kidney function (estimated GFR \< 60 mls/min/1.73m2 by MDRD equation\[18\]).
Minimum age 20 years
Able to return to the study site for followup blood work.

Exclusion

Estimated GFR \< 15 mls/min/1.73m2 by MDRD equation
Already on dialysis
Known current acute kidney failure with serum creatinine rise of \> 45 mol/L within 24 hours
Pulmonary edema - current or within 48 hours
Clinically significant ascites, edema or other fluid overload
Uncontrolled hypertension (\> 165 mmHg systolic, or \> 105 mmHg diastolic)
Unstable patient requiring IV nitroglycerine, or IV fluid or inotropes for BP support
Emergency angiography
Planned primary PCI for acute coronary syndrome or myocardial infarction
Exposure to iodinated radiocontrast within 3 days prior to study
Prior anaphylactoid reaction to contrast
Planned administration of N-acetyl-cysteine, dopamine, fenoldopam or mannitol

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT00749827

Last Update

April 20 2016

Active Locations (2)

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Page 1 of 1 (2 locations)

University of Alberta Hospital

Edmonton, Alberta, Canada, T6G 2G3