Status:
TERMINATED
Comparative Evaluation of MRI and MDCT for the Detection of Metastic Pulmonary Nodules
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Metastatic Pulmonary Nodules
Eligibility:
All Genders
2-18 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to apply the techniques of dynamic MRI imaging enhancement to research participants with one or more pulmonary nodule to determine if meaningful information about the natu...
Detailed Description
The gold standard for investigating the detection of pulmonary metastases is Multi-Detector Computed Tomography (MDCT). Computed Tomography (CT) is routinely used in the staging of pediatric patients ...
Eligibility Criteria
Inclusion
- Patients between 2-18 years of age
- Patients who present themselves to the Department of Diagnostic Imaging at the Hospital for Sick Children for CT of the thorax
- Patients undergoing a CT of the thorax for detection of lung metastases following diagnosis of a solid tumor or suspected solid tumor
- Patients who present themselves for initial diagnosis or at follow up CT for progression
- Able to give informed consent (parents or patients)
Exclusion
- Usual exclusion criteria for MRI (e.g. pacemaker, ocular metal, claustrophobia)
- Have any known allergy to one or more of the ingredients in the study contrast agents; have a history of hypersensitivity to any metals or chelates of gadolinium; have a history of allergies or bronchial asthma; use beta blockers, have cardiovascular disease; or have anaphylactic reactions
- Have moderate-to-severe renal impairment (defined as having a GFR/ eGFR \< 60 mL/min)
- Have sickle cell anemia
- MRI of the chest requiring sedation or general anesthesia
- Known pregnancy or breast feeding
- Renal failure
- Patient uncooperative during a MRI without sedation or anesthesia (unless already receiving this for MRI of another body region)
- Children under the age of 2 will not be eligible for intravenous contrast
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT00751920
Start Date
August 1 2008
End Date
December 1 2010
Last Update
January 5 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Hospital for Sick Children
Toronto, Ontario, Canada