Status:
COMPLETED
Exercise and Inflammation in the Elderly
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
University of Maryland
Johns Hopkins University
Conditions:
Inflammation
Insulin Sensitivity
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
Persistent low-grade inflammation and impaired fibrinolysis, are independent predictors of several chronic diseases highly prevalent in the older Veteran population including cardiovascular disease (C...
Detailed Description
This study will compare the effects of 6 month trial of aerobic exercise (AEX) vs. weight loss (WL) in older individuals on: 1. adipokine secretion and expression (tumor necrosis factor alpha, adipon...
Eligibility Criteria
Inclusion
- Male and Female
- 45-80 yrs of age
- Non-smoking for one year
- Body mass index greater than 20 kg/m2 and less than 50 kg/m2
- Menopause over 1 year
Exclusion
- Symptomatic heart disease, coronary artery disease, congestive heart failure, or uncontrolled hypertension (blood pressure over 180/100 mm Hg) unless medically stabilized
- Currently being treated for active cancer
- Type 1 diabetes; Insulin or oral agent treatment for diabetes, poorly controlled diabetes fasting blood glucose over 160 mg/dl
- Allergic to lidocaine
- Untreated dyslipidemia with National Cholesterol Adult Treatment Panel III 10 year cardiac risk score greater than 10%, or receiving triglyceride lowering meds
- Other systemic disorders that are not medically treated and stable
- Taking beta-blockers, oral steroids, warfarin or any other medications interfering with fat/muscle metabolism that may not be safely discontinued temporarily for specific procedures (ie for 72 hours prior)
- Abnormal response to exercise test (ST segment depression greater than 2mm, chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising BP above 240/120mm Hg, or other contraindications to exercise) \*requires follow up treatment w/ primary MD for continued participation in study
- Abnormal liver function
- Abnormal renal function
- Chronic pulmonary disease
- Anemia hematocrit below 35 mg/dl, platelets below 100,000/cm3
- Mini-mental state exam below 24, dementia or unstable clinical depression by exam
- Aerobically trained with maximal oxygen consumption greater than 2 standard deviations above age-adjusted mean
- Exercise group only: History of cerebrovascular disease (by medical history) with symptoms limiting the ability to exercise
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 29 2012
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT00753363
Start Date
April 1 2007
End Date
November 29 2012
Last Update
June 26 2018
Active Locations (1)
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1
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States, 21201