Status:
COMPLETED
Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
2-2 years
Phase:
PHASE1
Brief Summary
The objective of the study is to determine whether or not inhalation of hypertonic saline will be tolerated by infants with cystic fibrosis and the effect of inhalation on their lung function.
Detailed Description
Cystic fibrosis lung disease is characterized by mucous retention which favors secondary bacterial infection and inflammation, which leads to lung damage and ultimately respiratory failure. Classicall...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of cystic fibrosis
- Age 2 months to 2 years
- Routinely scheduled infant pulmonary function test.
- Clinical stability (no respirator tract infection for 4 weeks prior to study
Exclusion
- Acute respiratory symptoms
- Wheezing at the time of study
- Supplemental oxygen therapy
- Oxygen saturation \< 95 % on room air
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2007
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00753987
Start Date
March 1 2006
End Date
January 1 2007
Last Update
February 13 2025
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8