Status:
COMPLETED
The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED)
Lead Sponsor:
Taipei Veterans General Hospital, Taiwan
Conditions:
Ischemic Stroke
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
Eligibility Criteria
Inclusion
- Patient With Tia Or Ischemic Stroke (Event Has Occurred More Thaan 4 Weeks But Less Than 24 Weeks, And Modified Rankin'S Scale, Mrs\<=3) With Mild To Moderate Hypertension
- Patient Has No Other Active Medical Problem, Which Might Of Itself Or By This Treatment Significantly Affect The Patient's Blood Pressure
- The Blood Level Of Hscrp\>0.2 Ng/Dl By Two Measurements Performed Respectively One-Week Apart
Exclusion
- Patients With Cardiac Arrhythmia
- Diabetes Mellitus
- Patient With Other Active Inflammatory Diseases Such As Rheumatoid Disease, Fever And Systemic Infection Which Will Confound The Level Of Serum CRP
- Patients With Known Intolerance, Contraindication Or Hypersensitivity To Losartan, Amlodipine and Hydrochlorothiazide
- Patient With Myocardial Infarction Within The Recent Three Months
- Anatomy Abnormality Which Results In Poor Bilateral Temporal Acoustic Windows Which Prevent TCD Procedure
- Patient Who Requires Continuous Medication With Alpha Blocking Agents
- Concurrent Usage Of Acei
- Poor Mental Function Or Any Other Reason To Expect Difficulty In Meeting The Requirements Of The Study
- Concurrent Treatment With Other Lipid-Lowering Drug
- Childbearing Potential Women Not Undergoing Adequate Contraceptive Control
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00754429
Start Date
June 1 2004
End Date
July 1 2009
Last Update
October 23 2013
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