Status:
COMPLETED
Effects of Cardiac Rehabilitation on High Mobility Group Box-1 Levels After Acute Myocardial Infarction
Lead Sponsor:
Federico II University
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
35-75 years
Phase:
NA
Brief Summary
This purpose of this study is to examine the relationship between HMGB-1 and postinfarction predictors of outcome such as cardiopulmonary and echocardiographic parameters before and after a 6-month ex...
Detailed Description
Exercise-based Cardiac Rehabilitation after acute myocardial infarction (AMI) has beneficial effects on cardiovascular functional capacity, quality of life, risk factors modification, and morbidity an...
Eligibility Criteria
Inclusion
- Acute Myocardial Infarction
Exclusion
- BMI higher than 30 and lower than 18
- Residual myocardial ischemia
- Severe ventricular arrhythmias
- IIb or III degree atrio-ventricular block
- Valvular disease requiring surgery
- Pericarditis
- Severe renal dysfunction (i.e. creatinine \>2.5 mg/dl)
- Severe concomitant non-cardiac disease such as cancer
- Liver dysfunction (alanine aminotransferase/aspartate aminotransferase level \>1.5 times the upper normal limit)
- Dementia
- Any systemic disease limiting exercise
- Inability to participate in a prospective study for any logistic reason
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00755131
Start Date
September 1 2008
End Date
October 1 2009
Last Update
February 2 2010
Active Locations (1)
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1
University of Naples "Federico II"
Naples, Italy, 80131