Status:
COMPLETED
A Study of the Effects of Exercise Intensity on Insulin Sensitivity in Overweight Youth
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
Manitoba Institute of Child Health
Conditions:
Type 2 Diabetes Mellitus
Adolescent Obesity
Eligibility:
All Genders
13-19 years
Phase:
PHASE4
Brief Summary
Background: The investigators know that exercise helps children develop strong bones and muscles and generally stay healthy. What is unclear however, is how much exercise a child needs to lower their...
Detailed Description
The Physical activity for OverWEight youth at Risk for type 2 diabetes (POWER) Trial is a randomized controlled clinical trial designed to study the effects of aerobic exercise training regimens diffe...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Ethnic minority considered at risk for T2DM
- In utero exposure to hyperglycemia (i.e. mother with gestational or frank diabetes during pregnancy) and/or evidence of hepatic steatosis (serum ALT \> 60U/L, ultrasound or MRI-based evidence of steatosis).
- Exclusion criteria:
- The investigators will exclude any patients that may have altered insulin sensitivity or tissue lipid content that would confound (mask) the effects of the intervention.
- These include overweight adolescents who:
- are diagnosed with impaired glucose tolerance or type 2 diabetes
- are currently being treated with corticosteroids or atypical antipsychotics, as these agents significantly influence carbohydrate metabolism
- are undergoing puberty (Tanner Stage 2-4) at the time of the investigation, as it is associated with transient changes in insulin sensitivity
- have an orthopaedic injury that would prevent them from performing the intervention
- have experienced weight loss or enrolled in weight loss program in the six months prior to the study
- have a history of alcoholism or drug abuse.
Exclusion
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00755547
Start Date
April 1 2008
End Date
January 1 2013
Last Update
March 29 2013
Active Locations (1)
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1
Manitoba Institute of Child Health
Winnipeg, Manitoba, Canada, R3E3P4