Status:
COMPLETED
A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
Lead Sponsor:
University of Oklahoma
Conditions:
Myocardial Ischemia
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups. Our hypothesis is that the meto...
Detailed Description
Beta-receptor antagonists are commonly used in the perioperative setting. These agents have been shown to decrease the incidence of perioperative myocardial ischemia and are recommended by a recent pr...
Eligibility Criteria
Inclusion
- Being older than 18 but, not older than 75
- Scheduled for surgery under general anesthesia
- Duration of surgery scheduled as 2 hours or longer
Exclusion
- Intracranial or intrathoracic surgery (due to difficulty using a BIS monitor or frequent need for beta-receptor antagonism)
- Indication for perioperative beta-receptor antagonism
- Current use of calcium-channel antagonists
- History of coronary artery disease
- History of reactive airway disease
- History of diabetes or other disorders of glucose metabolism
- Reported allergy to any of the study drugs
- Reported substance abuse (except nicotine and caffeine)
- Use of monoamine oxidase (MAO) inhibitor drugs
- Hypersensitivity to metoprolol, esmolol and related derivatives, or to any of the excipients of either.
- Hypersensitivity to other beta-blockers (cross-sensitivity between beta-blockers can occur).
- Sick-sinus Syndrome.
- Heart block greater than first degree, cardiogenic shock, and overt cardiac failure.
- Significant first-degree heart block (P-R interval greater than or equal to 0.24 sec; systolic pressure \< 100mmHg; or moderate- to-severe cardiac failure).
- Severe peripheral arterial circulatory disorders.
- Pheochromocytoma.
- Baseline heart rate of \< 60
- Systolic pressure less than 100 mm Hg
- Pregnant women
- Prisoners
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 2 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00756236
Start Date
October 1 2008
End Date
September 2 2015
Last Update
July 31 2017
Active Locations (1)
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1
Univeristy of Oklahoma Health Sciences Center Dept. Anesthesiology
Oklahoma City, Oklahoma, United States, 73104